Liver Dysfunction due to Anti-Thyroid Drugs

Liver dysfunction and anti-thyroid therapy

Thioamides have been used in the management of hyperthyroidism for over 50 years. Liver dysfunction is a rare but important side effect associated with their use. Recently, cases of liver failure associated with propylthiouracil have prompted the Federal Drug Administration to issue a Boxed Warning to the label of propylthiouracil regarding its risk of potentially fatal liver injury and acute l...

Biloma due to blunt liver trauma

Background: Biloma is a rare abnormal localized accumulation of bile out of biliary tree due to an injury. It has different non-specific clinical features and its diagnosis is based on clinical signs, radiologic findings and chemical analysis of aspirated liquid. Considering the non-specific clinical features, early diagnosis and treatment can have an effective role in the decrease of complicat...

Rickets Due To Prolonged Use of Antiepileptic Drugs

La therapeutique ant epileptique de longue duree provoque une profonde modification du metabolisme de la vitamine B et notamment une acceleration du catabolisme de celle-ci.  Les auteurs rapportent un cas de ce type particulier d'osteomalacie et la revue de la lit­terature leur permet de souligner trois points essentiels:  1 ) les besoins journaliers de la vitamine B sontaccrus chez les enfan...

Anti-tuberculosis drugs and liver toxicity.

anti-thyroid drugs-related myopathy: is carbimazole the real culprit?

case presentation a 28-year old chinese female was treated with carbimazole (cmz) for graves’ disease with hyperthyroidism. two weeks later, she developed myalgia and proximal muscle weakness. investigations showed evidence of myopathy. cmz was stopped and rapid improvement of clinical condition and biochemical parameters ensued. conclusions rapid decrement of thyroid hormone level is recognize...